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Search Results for " notch ligand dll4 "

1

抑制剂 & 化合物

4

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T80615 Enoticumab

REGN421

Enoticumab(REGN421,SAR153192)是一种针对人类Dll4的IgG1κ类型抗体。DLL4Notch信号通路中的关键配体,其功能通过巨胞饮作用依赖的非转录调控机制影响长链脂肪酸的摄取。该抗体在卵巢癌异种移植模型中展示出明确的体内活性,其中EGN421(2.5mg/kg,周剂量)在小鼠皮下TOV-112D及腹膜内A2780人类肿瘤异种移植模型中实现了分别达到86%和83%的肿瘤生长抑制效果。

化合物

Enoticumab
Cat.No: T80615
Synonym: REGN421
Target:
Cat. No. Product Name Species Expression System
TMPK-00360 DLL4 Protein, Human, Recombinant (His & Avi)

notch ligand DLL4,MGC126...

Human HEK293 Cells
Delta-like protein 4 (DLL4) is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibit...
TMPY-05093 DLL4 Protein, Rhesus, Recombinant (His)

delta-like 4 (Drosophila),δ-like 4 (Drosop...

Rhesus HEK293 Cells
DLL4 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.1 kDa and the accession number is XP_001099250.1.
TMPY-01337 DLL4 Protein, Mouse, Recombinant (His)

Dll44,delta-like 4 (Dr...

Mouse HEK293 Cells
DLL4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55.7 kDa and the accession number is Q9JI71.
TMPY-06876 DLL4 Protein, Human, Recombinant (His & Avi), Biotinylated

hδ2,δ-like 4,Delta-like 4,δ-like 4

Human HEK293 Cells
DLL4 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 57.55 kDa and the accession number is NP_061947.1.

重组蛋白

DLL4 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00360
Species: Human
Expression System: HEK293 Cells
DLL4 Protein, Rhesus, Recombinant (His)
Cat.No: TMPY-05093
Species: Rhesus
Expression System: HEK293 Cells
DLL4 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01337
Species: Mouse
Expression System: HEK293 Cells
DLL4 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-06876
Species: Human
Expression System: HEK293 Cells
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